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MOG vs. Hooke runs most commonly-used EAE models. Click here for an overview of EAE and a list of models offered. It has a large therapeutic window, good sensitivity, and very good predictive value for efficacy in MS. This model may also be used to test neuronal regeneration. The disease induced by either antigen is similar, except that EAE induced by whole MOG protein is reported to be dependent on B cells ; this may be of interest if your compound targets B cells.
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